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Neural Tube Research Funded Print
Tuesday, 02 June 2015 07:36

neural tube

Dr. Jessica Sullivan-Brown was awarded $10,000 by the West Chester University Foundation to study the roles of folic acid metabolism genes in neural tube development.

The neural tube is a precursor to the brain and spinal cord, and neural tube defects, like spina bifida, are common and severe congenital conditions. Dietary supplementation of folic acid decreases the incidence of neural tube defects; however, the effects of folic acid on neural tube development are unclear. Folic acid metabolism has many important cellular roles and is thought to be critical for rapidly growing tissues like the neural tube.

Graduate student Patricia Bianchino will be analyzing the RNA expression of folic acid metabolism genes in the neural tube to determine if expression is enriched in the neural tube.  She will be analyzing the expression of folic acid metabolism genes during neural tube development in the frog Xenopus laevis. Xenopus laevis is a commonly used model system for studying neural tube defects because neural tube development is similar to humans and many genes are conserved.

 

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